TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration

TREM2 is strongly linked to Alzheimer ’s disease risk, but its functions are not fully understood. Zhong et al. discovered that TREM2 suppresses complement activity and synaptic loss by binding to C1q. They identified a 41-amino-acid TREM2 peptide that restricts complement-mediated synaptic elimination during neurodegeneration.

Source: Immunity - July 12, 2023 Category: Allergy & Immunology Authors: Li Zhong, Xuan Sheng, Wanbing Wang, Yanzhong Li, Rengong Zhuo, Kai Wang, Lianshuai Zhang, Dan-Dan Hu, Yujuan Hong, Linting Chen, Hengjun Rao, Tingting Li, Muyang Chen, Zhihao Lin, Yun-wu Zhang, Xin Wang, Xiao-Xin Yan, Xiaochun Chen, Guojun Bu, Xiao-Fen Ch Tags: Article Source Type: research