Regulation of coagulation activation in newly diagnosed AML by the heme enzyme myeloperoxidase

Patients with acute myeloid leukemia (AML) are at increased risk of thrombohemorrhagic complications. Overexpressed tissue factor (TF) on AML blasts contributes to systemic coagulation activation. We have recently shown that the heme enzyme myeloperoxidase (MPO) negatively regulates TF procoagulant activity (PCA) on myelomonocytic cells in vitro. We now aimed to further characterize the functional interaction of MPO and TF in AML in vivo.

Source: Thrombosis Research - July 11, 2023 Category: Hematology Authors: Florian Langer, Hanna Quick, Antonia Beitzen-Heineke, Snjezana Janjetovic, Jonathan M äder, Carina Lehr, Carsten Bokemeyer, Piotr Kuta, Thomas Renné, Walter Fiedler, Lennart Beckmann, Felix Klingler, Christina C. Rolling Tags: Full Length Article Source Type: research