Radiotherapy Sensitization With Ultrasound-Stimulated Intravenously Injected Oxygen Microbubbles Can Have Contrary Effects Depending on the Study Model

We are writing to share our collective experience over the last few years working on radiosensitization strategies using intravenously administered, ultrasound-stimulated, oxygen microbubbles. There has been considerable pre-clinical success reported to date, including from our own groups, using oxygen microbubbles as a cancer theranostic agent to improve radiotherapy, sonodynamic therapy and brachytherapy treatments [1 –4]. However, we have recently come across several unexpected findings that warrant further study and caution as these techniques move toward translation.

Source: Ultrasound in Medicine and Biology - July 11, 2023 Category: Radiology Authors: Virginie Papadopoulou, Eleanor P. Stride, Mark A. Borden, John R. Eisenbrey, Paul A. Dayton Tags: Letter to the Editor-in-Chief Source Type: research