Cryptic KMT2A/MLLT10 fusion detected by next-generation sequencing in a case of pediatric acute megakaryoblastic leukemia

KMT2A rearrangement is a common chromosomal aberration that occurs in about 10% of acute leukemias [1]. KMT2A (11q23.3; formerly MLL) gene rearrangements are found in both pediatric and adult acute leukemias and associated with a poor or intermediate prognosis [2]. KMT2A has a number of gene fusion partners, with MLLT10 (10p12.31; formerly AF10) being the fourth most common. Although it has been documented in congenital and infant leukemia, therapy-related acute myeloid leukemia (AML), B- and T-lymphoblastic leukemia/lymphoma, and mixed-phenotype acute leukemia (MPAL), KMT2A/MLLT10 fusion is most commonly seen in pediatric AML [3 –6].
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Tags: Short Communication Source Type: research