Hypoadiponectinemia-induced upregulation of microRNA449b downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury in diabetic mice

Diabetes enhances myocardial ischemic/reperfusion (MI/R) injury via an incompletely understood mechanism. Adiponectin (APN) is a cardioprotective adipokine suppressed by diabetes. However, how hypoadiponectinemia exacerbates cardiac injury remains incompletely understood. Dysregulation of miRNAs plays a significant role in disease development. However, whether hypoadiponectinemia alters cardiac miRNA profile, contributing to diabetic heart injury, remains unclear. Methods and Results: Wild-type (WT) and APN knockout (APN-KO) mice were subjected to MI/R.

Source: Journal of Molecular and Cellular Cardiology - July 10, 2023 Category: Cytology Authors: Zhijun Meng, Bin Liang, Yalin Wu, Caihong Liu, Han Wang, Yunhui Du, Lu Gan, Erhe Gao, Wayne B. Lau, Theodore A. Christopher, Bernard L. Lopez, Walter J. Koch, Xinliang Ma, Fujie Zhao, Yajing Wang, Jianli Zhao Source Type: research