CD26 CAR-T cells have attenuated mitochondrial and glycolytic metabolic profiling

CONCLUSION: CD26 CAR-T cells showed distinctive metabolic profiling during expansion that was extremely unfavorable to cell persistence and function. These findings may provide new insights for the optimization of CD26 CAR-T cells in terms of metabolism.PMID:37382435 | DOI:10.1080/08923973.2023.2231632

Source: Immunopharmacology and Immunotoxicology - June 29, 2023 Category: Allergy & Immunology Authors: Xiaoying Zhu Zhaodong Zhong Fankai Meng Ping Zou Yong You Qing Li Xiaojian Zhu Source Type: research