Kinematic adaptive deep brain stimulation for gait impairment and freezing of gait in Parkinson's disease

Gait impairment and freezing of gait (GI&FOG) are debilitating symptoms of Parkinson's disease (PD), which increase the risk of falls, injury, and morbidity, and may be refractory to medication [1]. Open loop deep brain stimulation (olDBS) improves GI&FOG [2,3], but the observed improvement may lose efficacy over time. The waning of efficacy over time and the disabling side effects of combining olDBS with medication have highlighted the potential of demand-based or adaptive DBS (aDBS), where DBS intensity is modulated in response to a biomarker that is related to the pathological motor behavior targeted.

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 8, 2023 Category: Neurology Authors: Jillian A. Melbourne, Yasmine M. Kehnemouyi, Johanna J. O'Day, Kevin B. Wilkins, Aryaman S. Gala, Matthew N. Petrucci, Emilia F. Lambert, Hannah Dorris, Cameron Diep, Jeffrey A. Herron, Helen M. Bronte-Stewart Source Type: research