Progressive Orthopnea and Bendopnea Due to Diaphragmatic Paralysis Associated With IgLON5 Autoimmunity

A man in his late 60s presented with a 2-year history of rapid eye movement behavioral disorder (RBD), progressive dyspnea, and orthopnea. He also reported marked shortness of breath when he bent over (bendopnea).1 He had vocal cord paralysis 11 years ago. Neurological examination revealed right deltoid fasciculations. Deep tendon reflexes were brisk. Babinski sign was absent. Thorough cardiac work-up including echocardiography was unremarkable. Because of the presence of brisk reflexes, fasciculations, and progressive dyspnea, the patient was referred for evaluation of motor neuron disease (MND).
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Medical image Source Type: research