Molecules, Vol. 28, Pages 5053: Rhodiola rosea L. Extract, A Known Adaptogen, Evaluated in Experimental Arthritis

Molecules, Vol. 28, Pages 5053: Rhodiola rosea L. Extract, A Known Adaptogen, Evaluated in Experimental Arthritis Molecules doi: 10.3390/molecules28135053 Authors: Frantisek Drafi Katarina Bauerova Martin Chrastina Mohsen Taghdisiesfejír João Rocha Rosa Direito Maria Eduardo Figueira Bruno Sepodes Silvester Ponist Rhodiola rosea L. extract (RSE) is mostly known for its adaptogen properties, but not for its antiarthritic activities, therefore monotherapy and combination with low-dose methotrexate (MTX) was studied. The collagen-induced arthritis (CIA) model was used to measure the functional score, and the change in hind paw volume (HPV). Both parameters had significant antiarthritic effects. Based on these preliminary results, an adjuvant arthritis (AA) model was further applied to assess another parameters. The experiment included these animal groups: healthy controls, untreated AA, AA administered with RSE (150 mg/kg b.w. daily, p.o.), AA administered by MTX (0.3 mg/kg b.w. twice a week, p.o.), and AA treated with the combination of RSE+MTX. The combination of RSE+MTX significantly reduced the HPV and increased the body weight. The combination significantly decreased HPV when compared to MTX monotherapy. The plasmatic levels of inflammatory markers (IL-6, IL-17A, MMP-9 and CRP) were significantly decreased by MTX+RSE treatment. The RSE monotherapy didn’t influence any of the inflammatory parameters studied. In CIA, the RSE monotherapy...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research