Molecules, Vol. 28, Pages 5053: Rhodiola rosea L. Extract, A Known Adaptogen, Evaluated in Experimental Arthritis
Molecules, Vol. 28, Pages 5053: Rhodiola rosea L. Extract, A Known Adaptogen, Evaluated in Experimental Arthritis
Molecules doi: 10.3390/molecules28135053
Authors:
Frantisek Drafi
Katarina Bauerova
Martin Chrastina
Mohsen Taghdisiesfejír
João Rocha
Rosa Direito
Maria Eduardo Figueira
Bruno Sepodes
Silvester Ponist
Rhodiola rosea L. extract (RSE) is mostly known for its adaptogen properties, but not for its antiarthritic activities, therefore monotherapy and combination with low-dose methotrexate (MTX) was studied. The collagen-induced arthritis (CIA) model was used to measure the functional score, and the change in hind paw volume (HPV). Both parameters had significant antiarthritic effects. Based on these preliminary results, an adjuvant arthritis (AA) model was further applied to assess another parameters. The experiment included these animal groups: healthy controls, untreated AA, AA administered with RSE (150 mg/kg b.w. daily, p.o.), AA administered by MTX (0.3 mg/kg b.w. twice a week, p.o.), and AA treated with the combination of RSE+MTX. The combination of RSE+MTX significantly reduced the HPV and increased the body weight. The combination significantly decreased HPV when compared to MTX monotherapy. The plasmatic levels of inflammatory markers (IL-6, IL-17A, MMP-9 and CRP) were significantly decreased by MTX+RSE treatment. The RSE monotherapy didn’t influence any of the inflammatory parameters studied. In CIA, the RSE monotherapy...
Source: Molecules - Category: Chemistry Authors: Frantisek Drafi Katarina Bauerova Martin Chrastina Mohsen Taghdisiesfej ír Jo ão Rocha Rosa Direito Maria Eduardo Figueira Bruno Sepodes Silvester Ponist Tags: Article Source Type: research