Small molecule fluorescent probes for the study of protein phase separation

Curr Opin Chem Biol. 2023 Jun 24;76:102354. doi: 10.1016/j.cbpa.2023.102354. Online ahead of print.ABSTRACTLiquid-liquid phase separation (LLPS) and liquid-solid phase transitions (LSPT) play crucial roles in biological systems, including sorting biomolecules, facilitate the transport of substrates for assembly, and accelerate the formation of metabolic and signaling complexes. Efforts towards improved characterization and quantification of phase separated species remain of outstanding interest and priority. In this review, we cover recent advances and the strategies used with small molecule fluorescent probes for the study of phase separation.PMID:37364418 | DOI:10.1016/j.cbpa.2023.102354
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Source Type: research