Intracranial electrical stimulation of corticolimbic sites modulates arousal in humans

Humans routinely shift their sleepiness and wakefulness levels in response to emotional factors. The diversity of emotional factors that modulates sleep-wake levels suggests that the ascending arousal network may be intimately linked with networks that mediate mood. Indeed, while animal studies have identified select limbic structures that play a role in sleep-wake regulation, the breadth of corticolimbic structures that directly modulates arousal in humans remains unknown.

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - June 27, 2023 Category: Neurology Authors: Joline M. Fan, Andrew M. Lee, Kristin K. Sellers, Kai Woodworth, Ghassan S. Makhoul, Tony X. Liu, Catherine Henderson, Daniella Astudillo, Rebecca Martinez, Hashem Zamanian, Benjamin Speidel, Ankit N. Khambhati, Vikram R. Rao, Leo P. Sugrue, Katherine W. Source Type: research