Pro-inflammatory markers are associated with response to sequential pharmacotherapy in major depressive disorder: a CAN-BIND-1 report

CONCLUSION: Higher pre-treatment levels of IFN-Γ and CCL-2 were associated with non-response to escitalopram. Increasing levels of these pro-inflammatory markers may be associated with non-response to adjunctive aripiprazole. These findings require validation in independent clinical populations.PMID:37218291 | DOI:10.1017/S109285292300233X

Source: CNS Spectrums - May 23, 2023 Category: Neurology Authors: M Ishrat Husain Jane A Foster Brittany L Mason Sheng Chen Haoyu Zhao Wei Wang Susan Rotzinger Sakina Rizvi Keith Ho Raymond Lam Glenda MacQueen Roumen Milev Benicio N Frey Daniel M üller Gustavo Turecki Manish Jha Madhukar Trivedi Sidney H Kennedy Source Type: research