Differential Response of Pelvic Bone Marrow FDG Uptake in Patients Receiving Concurrent Chemoradiotherapy

Irradiation of pelvic bone marrow (PBM) at the level of the typical low dose bath of intensity-modulated radiotherapy delivery (10 –20 Gy) is associated with an increased risk of haematological toxicity, particularly when combined with concurrent chemotherapy. Although sparing of the whole of the PBM at a 10–20 Gy dose level is unachievable, it is known that PBM is divided into haematopoietically active and inactive regions that are identifiable based on the threshold uptake of [18F]-fluorodeoxyglucose (FDG) seen on positron emission tomography-computed tomography (PET-CT).
Source: Clinical Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research