TL1A promotes the postoperative cognitive dysfunction in mice through NLRP3-mediated A1 differentiation of astrocytes

CONCLUSION: Our results demonstrate that TL1A plays an important role in POCD in mice, which promotes the A1 differentiation of astrocytes through NLRP3, thereby exacerbating the progression of cognitive dysfunction.PMID:37269079 | DOI:10.1111/cns.14290

Source: CNS Neuroscience and Therapeutics - June 3, 2023 Category: Neuroscience Authors: Genghuan Wang Jian Shen Liping Zhai Yingcong Lin Qiaobing Guan Heping Shen Source Type: research