Three new furanones from endophytic fungus < em > Hypoxylon vinosopulvinatum < /em > DYR-1-7 from < em > Cinnamomum cassia < /em > with their antifungal activity

Nat Prod Res. 2023 Jun 2:1-8. doi: 10.1080/14786419.2023.2218530. Online ahead of print.ABSTRACTHypoxylon vinosopulvinatum DYR-1-7 is a endophytic fungus isolated from the Cinnamomum cassia Presl and has an inhibitory effect on Lasiodiplodia pseudotheobromae. Three new furanones, hypoxylonone A-C (1-3), as well as three known compounds (4-6), were isolated from an EtOAc extract of H. vinosopulvinatum DYR-1-7. The structures were determined by spectroscopic data analysis using UV, IR, 1D-, 2D-NMR and HR-ESI-MS. The absolute configurations of 1-3 were elucidated by electronic circular dichroism (ECD) analyses. In the antifungal bioassay, Hypoxylonone B and C exhibited strong inhibitory effects on L. pseudotheobromae with IC50 value at the concentration of 1.01 and 2.40 μg/mL, respectively. Compound 6 showed medium antifungal activity with IC50 value at the concentration of 10.67 μg/mL on Fusarium oxysporum. Compounds 3 and 4 displayed medium antifungul effects on Candida albicans.PMID:37267595 | DOI:10.1080/14786419.2023.2218530
Source: Natural Product Research - Category: Biochemistry Authors: Source Type: research