Factors Affecting Ablation Success After I-131 Radioactive Iodine Therapy in Low and Intermediate Risk Papillary Thyroid Cancer
Horm Metab Res DOI: 10.1055/a-2077-7246The study was to evaluate the effect of radioactive iodine (RAI) treatment
application time and clinical, histopathological factors on ablation success in
patients with operated papillary thyroid cancer (PTC) in low and
intermediate-risk. One hundred sixty-one patients with PTC in the low and
intermediate-risk were evaluated. Most patients (89.4%) were in the
low-risk, and 10.6% were in the intermediate-risk. When the patients
were divided into two groups according to the date of receiving RAI treatment
after surgery, those who received early treatment (≤3 months)
constituted the majority of the patients (72.7%). Seventeen patients
received 1.85 Gigabecquerel (GBq), 119 3.7 GBq, 25 5.55 GBq RAI. Most patients
(82%) achieved ablation success after the first RAI treatment. The time
interval between surgery and RAI treatment did not affect ablation success.
Stimulated Tg level measured on the RAI treatment day was an independent
predictive factor for successful ablation (p<0.001). The cut-off value
of Tg found to predict ablation failure was 5.86 ng/ml. It was
concluded that 5.55 GBq RAI treatment could predict ablation success compared to
1.85 GBq dose (p=0.017). It was concluded that having a T1 tumor may
predict treatment success compared to a T2 or T3 tumor (p=0....
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Goksel, Sibel Avci, Ugur Tags: Original Article: Endocrine Care Source Type: research
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