Utility of Measurable Residual Disease (MRD) Assessment in Mantle Cell Lymphoma

This article reviews existing techniques used in MRD assessment for MCL and describes novel methods which may overcome existing limitations, including next-generation sequencing modalities. The use of circulating tumour DNA is explored, with techniques such as CAPP-Seq and PhasED-Seq demonstrating promise in B-lymphoproliferative disorders, though application in MCL requires further study. The other aspect of practice using MRD is identifying therapeutic options which can address a subclinical molecular relapse. Developing suitable interventions that can alter the disease trajectory based o n longitudinal MRD kinetics are needed to justify its incorporation into standard care.
Source: Current Treatment Options in Oncology - Category: Cancer & Oncology Source Type: research