Dietary Recommendations for Dysbetalipoproteinemia: A Need for Better Evidence

Dysbetalipoproteinemia (DBL, or type III hyperlipoproteinemia according to the Fredrickson-Levy-Lees classification (OMIM# 617347)) is a highly atherogenic multifactorial disorder of remnant lipoprotein metabolism. The disease susceptibility starts by the presence of a defective apolipoprotein E (apoE) that has a reduced affinity for hepatic lipoprotein receptors. ApoE2 homozygosity is the most frequent underlying genetic defect observed in DBL patients. However, the presence of lifestyle/metabolic secondary factors, mainly associated with triglycerides (TG)-rich lipoproteins overproduction, is required to induce an overt DBL phenotype.
Source: Journal of Clinical Lipidology - Category: Lipidology Authors: Tags: Review Article Source Type: research