Regulation of pericyte metabolic reprogramming restricts the AKI to CKD transition
Acute kidney injury (AKI) is associated with high morbidity and mortality and is recognized as a long-term risk factor for progression to chronic kidney disease (CKD). The AKI to CKD transition is characterized by interstitial fibrosis and the proliferation of collagen-secreting myofibroblasts. Pericytes are the major source of myofibroblasts in kidney fibrosis. However, the underlying mechanism of pericyte-myofibroblast transition (PMT) is still unclear. Here we investigated the role of metabolic reprogramming in PMT.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Cheng Xu, Quan Hong, Kaiting Zhuang, Xuejing Ren, Shaoyuan Cui, Zheyi Dong, Qian Wang, Xueyuan Bai, Xiangmei Chen Source Type: research