GABAergic signaling abnormalities in a novel CLU mutation Alzheimer's disease mouse model

The CLU rs11136000C mutation (CLUC) is the third most common risk factor for Alzheimer's disease (AD). However, the mechanism by which CLUC leads to abnormal GABAergic signaling in AD is unclear. To address this question, this study establishes the first chimeric mouse model of CLUC AD. Examination of grafted CLUC medial ganglionic eminence progenitors (CLUC hiMGEs) revealed increased GAD65/67 and a high frequency of spontaneous releasing events. CLUC hiMGEs also impaired cognition in chimeric mice and caused AD-related pathologies.

Source: Translational Research - May 19, 2023 Category: Research Authors: Chunxia Chen, Xihe Tang, Zhaohui Lan, Wan Chen, Hua Su, Weidong Li, Yaoxuan Li, Xing Zhou, Hong Gao, Xinwei Feng, Ying Guo, Meicun Yao, Wenbin Deng Source Type: research