Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy

In conclusion, our study demonstrates that Metrnl regulated lipid metabolism in the kidney by modula ting mitochondrial function and is a stress-responsive regulator of kidney pathophysiology, which sheds light on novel strategies for treating DKD and associated kidney diseases.Article HighlightsMetrnl is expressed in renal tubules and is reduced under diabetic conditions.The concentration of Metrnl in the kidney is correlated with lipid accumulation and serum creatinine.Metrnl-specific overexpression in the kidney or recombinant Metrnl administration alleviates renal injuries in diabetic mice.Metrnl regulates renal tubules lipid metabolism through Sirt3-AMPK/UCP1 signaling axis –mediated mitochondrial homeostasis.
Source: Diabetes - Category: Endocrinology Source Type: research