Estimation of baseline IgG antibody levels to 23 pneumococcal vaccine-type capsular polysaccharides in healthy vaccine na ïve Indian adults

Vaccine. 2023 May 10:S0264-410X(23)00497-8. doi: 10.1016/j.vaccine.2023.04.074. Online ahead of print.ABSTRACTSince immunological responses to pneumococcal vaccines are assessed by a fold-increase in antibody levels relative to pre-immunization levels, it is therefore critical to determine baseline antibody levels to establish putative threshold as a measure of normal response. Herein, for the first time, we measured baseline IgG antibody levels in 108 healthy unvaccinated Indian adults using WHO-recommended ELISA. Median baseline IgG concentration ranged between 0.54 µg/mL to 12.35 µg/mL. Highest levels of baseline capsule polysaccharide (cPS)-specific IgG were found against types 14, 19A, and 33F. Whereas, lowest baseline IgG levels were observed against types 3, 4, and 5. Overall, ∼79 % of study population had median baseline IgG levels ≥1.3 µg/mL against 74 % of cPS's. Substantial baseline antibody levels in unvaccinated adults were observed. The study would be critical in bridging gaps in baseline immunogenicity data and may offer a valuable foundation for evaluating immune response of Indian adults to pneumococcal vaccination.PMID:37173269 | DOI:10.1016/j.vaccine.2023.04.074

Source: Vaccine - May 12, 2023 Category: Allergy & Immunology Authors: Vandana Govindan Feroze A Ganaie Shincy M Ramakrishnan Shilpa Ravindran Akhila M Mavuppadi K L Ravikumar Source Type: research