[Research Article] A molecular switch in the scaffold NHERF1 enables misfolded CFTR to evade the peripheral quality control checkpoint

A molecular switch in a scaffolding protein enables a misfolded, but partially functional, cystic fibrosis protein to evade a quality control checkpoint.

Source: Signal Transduction Knowledge Environment - May 20, 2015 Category: Science Authors: Cláudia A. Loureiro, Ana Margarida Matos, Ângela Dias-Alves, Joana F. Pereira, Inna Uliyakina, Patrícia Barros, Margarida D. Amaral, Paulo Matos Source Type: news