Does the Association of Hashimoto's Thyroiditis with Differentiated Thyroid Cancer Really Have a Protective Role?
Horm Metab Res DOI: 10.1055/a-2065-0845The study is an investigation of aggressive tumor features, prognosis, and
disease-specific mortality rates of differentiated thyroid cancer (DTC) in the
presence of concomitant Hashimoto’s Thyroiditis (HT). The data of
patients with DTC followed in our tertiary care center between 2000–2022
were analyzed. Variables such as patient age, gender, preoperative serum
autoantibody levels, tumor characteristics, and treatment modalities were
obtained from medical records. The diagnosis of HT was based either on the
presence of a positive result in the pathological examination and/or on
antibody positivity. A total of 637 patients [mean±SD age,
44.9±13.5 years; 485 women [76.1%)] were included in the
analysis. The overall prevalence of coexistent HT was 22.9%
(n=146). The disease-specific mortality associated with DTC was
2.9%. DTC patients with HT compared to those without; have more positive
lymphovascular invasion (p<0.001), and lymph node metastases
(p<0.001). According to the Kaplan–Meier curves,
disease-specific survival rates among DTC patients without HT were significantly
higher than patients with HT (log-rank p=0.002). The disease-specific
mortality rate was 4.79% in DTC patients with HT, it was 1.43%
in those without HT. Hashimoto thyroiditis ...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Demir, Ahmet Numan Kara, Zehra Sulu, Cem Uysal, Serhat Sahin, Serdar Zulfaliyeva, Guldana Atar, Oznur Aydin Valikhanova, Nahida Ozturk, Tulin Ozkaya, Hande Mefkure Gonen, Mustafa Sait Tags: Original Article: Endocrine Care Source Type: research
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