Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Retrospective Study
This study was aimed to
investigate the risk factors of various types of LNM in PTC with tumor
diameter>1 cm. The clinical data of 2216 PTC patients were
retrospectively analyzed. Univariate and multivariate logistic regression models
were used to analyze the risk factors of LNM. In addition, the receiver operator
characteristic (ROC) curve was used to find the best cut-off value of CLNM for
predicting LLNM. Finally, the independent risk factors of LLNM were used to
construct the prediction of LLNM nomogram. Age≤55 years old, male,
bilateral lobe tumors, ETE, 2–3 cm tumor diameters, and fasting
plasma glucose (FPG) were independent risk factors for CLNM. The ROC curve
showed that the best cut-off value was 2.5. Age, male, bilateral lobe tumors,
tumor diameters≥2 cm and CLNM≥3 were significantly
associated with LLNM , while CLNM=1 or 2 was a protective factor for
LLNM. Only tumor diameters≥3 cm was significantly associated
with skip LLNM. The nomogram model (C-index=0.745) can be used to
predict LLNM in PTC patients and guide the clinical selection of appropriate
treatment options. Patients with high risk factors should undergo prophylactic
lymph node dissection. The nomogram we established has a good predictive ability
for LLNM, and for high-risk groups, it is necessary to activ...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Gong, Jiantao Zhu, Baining Liu, Wenji Shi, Chaoqun Xia, Chen Zeng, Liqin Lv, Yunxia Tags: Original Article: Endocrine Care Source Type: research
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