Therapeutic Effects of Vitamin D in Asthma and Allergy.

Therapeutic Effects of Vitamin D in Asthma and Allergy.
Mini Rev Med Chem. 2015 May 19;
Authors: Benettia C, Comberiatia P, Capristob C, Bonera AL, Peronic DG
Abstract
In recent years, low vitamin D status has been proposed as a putative risk factor for allergic diseases. A growing body of literature reports low vitamin D levels in atopic patients and supports an association between vitamin D deficiency and risk of adverse asthma and allergies outcomes. Therefore, it has been speculated that vitamin D supplementation may either prevent or reduce the risk of allergic diseases. Birth cohort studies addressing the role of vitamin D intake during pregnancy have shown conflicting results regarding allergy outcomes in offspring. Currently, only a few studies have tried to supplement vitamin D in asthmatic patients, often as an add-on therapy to standard asthma controller medications, and results are not all consistent. There is emerging data to show that vitamin D can enhance the anti-inflammatory effects of glucocorticoids and potentially be used as adjuvant therapy in steroid-resistant asthma. Recent in vivo data suggest that vitamin D supplementation may also reduce the severity of atopic dermatitis. This review examines the existing relevant literature focusing on vitamin D supplementation in the treatment of allergic diseases.
PMID: 25985947 [PubMed - as supplied by publisher]

Source: Mini Reviews in Medicinal Chemistry - May 19, 2015 Category: Chemistry Authors: Benettia C, Comberiatia P, Capristob C, Bonera AL, Peronic DG Tags: Mini Rev Med Chem Source Type: research