Self-delivering mRNA inhibitors of MK2 improve outcome after spinal cord injury

Functional recovery and tissue damage after spinal cord injury (SCI) are influenced by secondary damage mechanisms, including inflammation. The inflammatory response after SCI relies on a variety of cell types with both protective and cytotoxic functions. The macrophage derived MAPK-activated protein kinase 2 has been described as a critical regulator of inflammation with detrimental function after SCI. Targeted modification of inflammatory effector molecules after SCI faces challenges of optimal timing, dosage and location of administration.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Source Type: research