Yes-associated protein nuclear translocation promotes anabolic activity in human articular chondrocytes

Yes-associated protein (YAP) has been widely studied as a mechanotransducer in many cell types, but its function in cartilage is controversial. The aim of this study was to identify the effect of YAP phosphorylation and nuclear translocation on the chondrocyte response to stimuli relevant to osteoarthritis (OA).

Source: Osteoarthritis and Cartilage - April 24, 2023 Category: Rheumatology Authors: Y. Cui, M.Z. Miao, M. Wang, Q.P. Su, K. Qiu, L. Arbeeva, S. Chubinskaya, B.O. Diekman, R.F. Loeser Source Type: research