A functional genomics approach reveals suggestive quantitative trait loci associated with combined TLR4 and BCP crystal-induced inflammation and osteoarthritis

Basic calcium phosphate (BCP) crystals can activate the NLRP3 inflammasome and are potentially involved in the pathogenesis of osteoarthritis (OA). In order to elucidate relevant inflammatory mechanisms in OA, we used a functional genomics approach to assess genetic variation influencing BCP crystal-induced cytokine production.

Source: Osteoarthritis and Cartilage - April 25, 2023 Category: Rheumatology Authors: Viola Kl ück, Collins K. Boahen, Brenda Kischkel, Jéssica C. Dos Santos, Vasiliki Matzaraki, Cindy G. Boer, Joyce B.J. van Meurs, Genetics of Osteoarthritis (GO) consortium, Kiki Schraa, Heidi Lemmers, Helga Dijkstra, Megan P. Leask, Tony R. Merriman, T Source Type: research