Application of Topical Sandalore ® Increases Epidermal Dermcidin Synthesis in Organ-Cultured Human Skin ex vivo

Conclusion: In addition to demonstrating for the first time that DCD can be expressed by epidermal keratinocytes, our pilot study suggests that topical treatment of human skin with a cosmetic odorant (Sandalore ®) has the potential to alter the composition of the human skin microbiome through the selective upregulation of DCD. If confirmed, Sandalore® could become an attractive adjuvant, nondrug treatment for dermatoses characterized by dysbiosis due to overgrowth ofS. aureus andMalassezia, such as atopic dermatitis and seborrheic dermatitis.Skin Pharmacol Physiol
Source: Skin Pharmacology and Physiology - Category: Dermatology Source Type: research