Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation

Abnormal tau accumulation and cholinergic degeneration are hallmark pathologies in the brains of patients with Alzheimer ’s disease (AD). However, the sensitivity of cholinergic neurons to AD-like tau accumulat...

Source: Molecular Neurodegeneration - April 14, 2023 Category: Neurology Authors: Dongqin Wu, Nana Yu, Yang Gao, Rui Xiong, Luping Liu, Huiyang Lei, Sen Jin, Jiale Liu, Yingzhou Liu, Jiazhao Xie, Enjie Liu, Qiuzhi Zhou, Yanchao Liu, Shihong Li, Linyu Wei, Jingru Lv & hellip; Tags: Research article Source Type: research