Wdr5 is essential for fetal erythropoiesis and hematopoiesis

AbstractWDR5 is a highly conserved protein that performs multiple scaffolding functions in the context of chromatin. However, efforts to understand the function of WDR5 in normal tissues physiologically are quite limited so far. In our study, we explored the function of Wdr5 in erythropoiesis and hematopoiesis by using a  hematopoietic-specificWdr5 knockout mouse model. We found that loss ofWdr5 mediated byVav-iCre leads to embryonic lethality with defective erythropoiesis. In addition, Wdr5-deficiency completely impairs the  hematopoietic stem and progenitor cells function and might alter the immunophenotype of these stem cells and progenitors by decreasing c-Kit expression. Collectively, we identified the pivotal role of Wdr5 in fetal hematopoiesis and erythropoiesis as the de novo findings.
Source: Experimental Hematology and Oncology - Category: Cancer & Oncology Source Type: research