Stalled oligodendrocyte differentiation in IDH-mutant gliomas

ConclusionsOur studies show that despite differences in clinical manifestation and genomic alterations, all IDH-mutant gliomas resemble early stages of oligodendrocyte lineage and are stalled in oligodendrocyte differentiation due to blocked myelination program. These findings provide a framework to accommodate biological features and therapy development for IDH-mutant gliomas.

http://link.springer.com/10.1186/s13073-023-01175-6

Source: Genome Medicine - April 13, 2023 Category: Genetics & Stem Cells Source Type: research