Reduced quantity and function of pneumococcal antibodies are associated with exacerbations of COPD in SPIROMICS
Clin Immunol. 2023 Apr 6:109324. doi: 10.1016/j.clim.2023.109324. Online ahead of print.ABSTRACTWhile hypogammaglobulinemia is associated with COPD exacerbations, it is unknown whether frequent exacerbators have specific defects in antibody production/function. We hypothesized that reduced quantity/function of serum pneumococcal antibodies correlate with exacerbation risk in the SPIROMICS cohort. We measured total pneumococcal IgG in n = 764 previously vaccinated participants with COPD. In a propensity-matched subset of n = 200 with vaccination within five years (n = 50 without exacerbations in the previous year; n = 75 with one, n = 75 with ≥2), we measured pneumococcal IgG for 23 individual serotypes, and pneumococcal antibody function for 4 serotypes. Higher total pneumococcal IgG, serotype-specific IgG (17/23 serotypes), and antibody function (3/4 serotypes) were independently associated with fewer prior exacerbations. Higher pneumococcal IgG (5/23 serotypes) predicted lower exacerbation risk in the following year. Pneumococcal antibodies are inversely associated with exacerbations, supporting the presence of immune defects in frequent exacerbators. With further study, pneumococcal antibodies may be useful biomarkers for immune dysfunction in COPD.PMID:37030524 | DOI:10.1016/j.clim.2023.109324
Source: Clinical Immunology - Category: Allergy & Immunology Authors: David C LaFon Han Woo Neal Fedarko Antoine Azar Harry Hill Anne E Tebo Thomas B Martins MeiLan K Han Jerry A Krishnan Victor E Ortega Igor Barjaktarevic Robert J Kaner Annette Hastie Wanda K O'Neal David Couper Prescott G Woodruff Jeffrey L Curtis Nadia N Source Type: research
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