Elevated HMGB1 and sRAGE levels in cerebrospinal fluid of aneurysmal subarachnoid hemorrhage patients

Neuroinflammation after aneurysmal subarachnoid hemorrhage (aSAH) leads to poor outcome of patients. High mobility group box 1 (HMGB1) contributes to inflammation through binding to receptors for advanced glycation end-products (RAGE) in various diseases. We aimed to determine the production of these two factors after aSAH and their relationship with clinical features.

Source: Journal of Stroke and Cerebrovascular Diseases - March 3, 2023 Category: Neurology Authors: Xue-Hong Chu, Hui-Yu Hu, Ivan Steve Godje Godje, Li-Juan Zhu, Jia-Bao Zhu, Yong-Liang Feng, Hai Wang, Yi-Bo Zhang, Juan Huang, Xin-Gang Sun Source Type: research