Schisandrin B promotes senescence of activated hepatic stellate cell via NCOA4-mediated ferritinophagy

CONCLUSIONS: Sch B could ameliorate hepatic fibrosis through the promotion of activated HSCs senescence, which might be attributed to its induction of NCOA4-mediated ferritinophagy and subsequent iron overload.PMID:37010139 | PMC:PMC10071970 | DOI:10.1080/13880209.2023.2189908

Source: Pharmaceutical Biology - April 3, 2023 Category: Drugs & Pharmacology Authors: Mingyue Ma Na Wei Jieren Yang Tingting Ding Anping Song Lerong Chen Shuguo Zheng Huanhuan Jin Source Type: research