Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.

http://link.springer.com/10.1186/s13073-023-01173-8

Source: Genome Medicine - April 5, 2023 Category: Genetics & Stem Cells Source Type: research