Esketamine ameliorates post-stroke anxiety by modulating microglial HDAC3/NF- κB/COX1 inflammatory signaling in ischemic cortex

In conclusion, this study suggests esketamine could alleviate microglial activation, reduces inflammatory cytokine, and inhibits the expression of HDAC3 and NF-κB in the cortex of PSA mice to attenuate anxiety-like behavior. Our results provided a new potential therapeutic target for applying esketamine to PSA.PMID:36997050 | DOI:10.1016/j.ejphar.2023.175667

Source: European Journal of Pharmacology - March 30, 2023 Category: Drugs & Pharmacology Authors: Ailin Huang Yang Chen Shaoshuang Wang Hailiang Du Ao Guan Huanghui Wu Qian Zhai Na Duan Xuying Li Pin Zhao Yulin Zhu Juan Bai Ye Xiao Tingting Yang Qiang Wang Bin Deng Source Type: research