Human umbilical cord mesenchymal stem cells ameliorate acute graft-versus-host disease by elevating phytosphingosine

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for malignant hematologic diseases. However, acute graft-versus-host disease (aGVHD) is currently the main complication limiting the wide application of transplantation [1,2]. Clinically, approximately 40% –60% of patients may develop aGVHD, resulting in transplant-related mortality of up to 5% and thus seriously affecting the long-term survival of patients [3]. With no consistently effective interventions for aGVHD and alternative approaches that are at best only modestly helpful, identification of more potent prophylactic and therapeutic strategies is urgent.
Source: Experimental Hematology - Category: Hematology Authors: Tags: Article Source Type: research