Updates in the pathology of penile intraepithelial neoplasia

Penile intraepithelial neoplasia (PeIN) is the putative histologic precursor of penile squamous cell carcinoma. PeIN is classified into HPV-associated and HPV-independent (differentiated) (dPeIN). While HPV-associated PeIN is has been linked to the oncogenic effect of human papillomavirus (HPV), the HPV-independent pathway is driven by chronic inflammatory conditions. These two biologic pathways are associated with distinct histopathologic features. The most common morphologic patterns of HPV-associated PeIN are basaloid, warty, and mixed PeIN.
Source: Diagnostic Histopathology - Category: Pathology Authors: Tags: Mini-symposium: Updates in genitourinary pathology Source Type: research