Ex vivo reprogramming of human hematopoietic stem cells is accompanied by increased transcripts of genes regulating metabolic integrity

The ability of the long-term (LT)- hematopoietic stem cells (HSCs) to balance self-renewal with commitment decisions is determined by a well-coordinated, unique transcriptomic and metabolic network [1 –12]. The transcriptome controls the functional fitness of the mitochondrial network required to meet the bioenergetic demands of HSCs during normal homeostasis, adaptation to stress, self-renewal, and differentiation [13–16]. On the other, apart from regulating oxidative stress and survival, mi tochondria can act as signaling hubs to dictate cell fate decisions by regulating the transcriptomic landscape [17–19].
Source: Experimental Hematology - Category: Hematology Authors: Tags: Article Source Type: research