Injectable contraceptive Depo-Provera produces erratic beating patterns in patient-specific induced pluripotent stem cell –derived cardiomyocytes with long QT syndrome type 2

Long QT syndrome type 2 (LQT2) is caused by pathogenic variants in KCNH2. LQT2 may manifest as QT prolongation on an electrocardiogram and present with arrhythmic syncope/seizures and sudden cardiac arrest/death. Progestin-based oral contraceptives may increase the risk of LQT2-triggered cardiac events in women. We previously reported on a woman with LQT2 and recurrent cardiac events temporally related and attributed to the progestin-based contraceptive medroxyprogesterone acetate ( “Depo-Provera” [Depo]).

Source: Heart Rhythm - March 6, 2023 Category: Cardiology Authors: Alexa M. Pinsky, Xiaozhi Gao, Sahej Bains, CS John Kim, Julien Louradour, Katja E. Odening, David J. Tester, John R. Giudicessi, Michael J. Ackerman Source Type: research