Multiple Mechanisms Explain Genetic Effects at the CPED1-WNT16 Bone Mineral Density Locus

AbstractPurpose of ReviewChromosome region 7q31.31, also known as theCPED1-WNT16 locus, is robustly associated with BMD and fracture risk. The aim of the review is to highlight experimental studies examining the function of genes at theCPED1-WNT16 locus.Recent FindingsGenes that reside at theCPED1-WNT16 locus includeWNT16,FAM3C,ING3,CPED1, andTSPAN12. Experimental studies in mice strongly support the notion thatWnt16 is necessary for bone mass and strength. In addition, roles forFam3c andIng3 in regulating bone morphology in vivo and/or osteoblast differentiation in vitro have been identified. Finally, a role forwnt16 in dually influencing bone and muscle morphogenesis in zebrafish has recently been discovered, which has brought forth new questions related to whether the influence ofWNT16 in muscle may conspire with its influence in bone to alter BMD and fracture risk.
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research