Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy

Alzheimer Disease (AD) and cerebral amyloid angiopathy (CAA) are both characterized by amyloid- β (Aβ) accumulation in the brain, although Aβ deposits mostly in the brain parenchyma in AD and in the cerebrovasc...

Source: Molecular Neurodegeneration - March 16, 2023 Category: Neurology Authors: Monica Xiong, Chao Wang, Maud Gratuze, Fareeha Saadi, Xin Bao, Megan E. Bosch, Choonghee Lee, Hong Jiang, Javier Remolina Serrano, Ernesto R. Gonzales, Michal Kipnis and David M. Holtzman Tags: Research article Source Type: research