LncRNA GAS5 suppresses TGF- β1-induced transformation of pulmonary pericytes into myofibroblasts by recruiting KDM5B and promoting H3K4me2/3 demethylation of the PDGFRα/β promoter

CONCLUSION: GAS5 represses pericyte-myofibroblast transformation by inhibiting PDGFRα/β expression via KDM5B-mediated H3K4me2/3 demethylation in IPF, identifying GAS5 as an intervention target for IPF.PMID:36918759 | PMC:PMC10015786 | DOI:10.1186/s10020-023-00620-x

Source: Molecular Medicine - March 15, 2023 Category: Molecular Biology Authors: Yichun Wang Diyu Chen Han Xie Shuhua Zhou Mingwang Jia Xiaobo He Feifei Guo Yihuan Lai Xiao Xiao Tang Source Type: research