Human umbilical cord mesenchymal stem cells ameliorate acute graft versus host disease by elevating phytosphingosine

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for malignant hematological diseases. However, acute graft-versus-host disease (aGVHD) is currently the main complication limiting the wide application of transplantation.1, 2 Clinically, approximately 40-60% of patients may develop aGVHD, resulting in transplant-related mortality of up to 5% and thus seriously affecting the long-term survival of patients.3 With no consistently effective interventions for aGVHD and alternative approaches that are at best only modestly helpful, identification of more potent prophylactic and therapeutic strategies is urgent.
Source: Experimental Hematology - Category: Hematology Authors: Tags: Article Source Type: research