Cigarette smoking is a secondary cause of folliculin loss

Conclusions
Our study demonstrates that CS exposure is a secondary cause of FLCN deficiency due to the enhanced proteolysis, which promoted airway epithelial cell death.

Source: Thorax - March 15, 2023 Category: Respiratory Medicine Authors: Li, X., Lai, Y., Lane, Z., Strollo, H., Tanimura, K., Sembrat, J. C., Zou, C., Myerburg, M. M., Rojas, M., Shapiro, S., Jiang, Y., Nyunoya, T. Tags: Open access, Thorax Smoking Source Type: research