A parasitic nematode induces dysbiosis in susceptible but not resistant gastropod hosts

What role does the microbiome play when we are infected with parasites? Using 16S metagenomics, we found one slug species infected with parasitic nematodes undergoes dysbiosis, however, a resistant slug does not. The nematode could be manipulating the host microbiome, or the bacterial communities may be altered due to ill health. How the resistant slug combats nematodes is unknown, but perhaps the bacterial communities in the microbiome play a role. AbstractAnimals ’ gut microbiomes affect a wide array of biological processes including immunity and protection from pathogens. However, how the microbiome changes due to infection by parasites is still largely unknown, as is how the microbiome changes in hosts that differ in their susceptibility to parasites. To investigate this, we exposed two slug species of differing susceptibility to the parasitic nematodePhasmarhabditis hermaphrodita (Deroceras reticulatum is highly susceptible andAmbigolimax valentianus resistant to the nematode) and profiled the gut microbiota after 7 and 14 days. Before infection, both slug species ’ microbiota was dominated by similar bacterial genera:Pseudomonas (by far the most abundant),Sphingobacterium, Pedobacter, Chryseobacterium, andFlavobacterium. In the resistant hostA. valentianus, there was no significant change in the bacterial genera after infection, but inD. reticulatum, the bacterial profile changed, with a decrease in the abundance of Pseudomonadaceae and an increase in the abundance ...
Source: MicrobiologyOpen - Category: Microbiology Authors: Tags: ORIGINAL ARTICLE Source Type: research