Mitotic Recombinatory Evolution in Acute Leukemia

Clonal evolution in cancer primarily involves selection for genomic alterations associated with oncogenic gene fusions, loss of tumor suppressor genes, or mutations of genes associated with oncogenic pathways. These alterations can also act as selection drivers for mitotic recombination that results in segmental replacement of the normal homologous region in the other chromosome homologue during development of the neoplasm. This can result in double translocation derivatives, biallelic mutations, and/or homozygotic tumor suppressor gene loss associated with selective advantage.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research