Blood metal levels linked with hematological, oxidative, and hepatic-renal function disruption in Swiss albino mice exposed to multi-metal mixture

AbstractThis study evaluates the toxic effect of various doses of multi-metal mixtures leading to metal accumulation in the blood of exposed mice and alterations in the blood biomarkers. To explore the health consequence of multiple metal exposures,Swiss Albino mice were orally given different doses of metal mixtures via drinking water for 8  weeks. The mice were randomly divided into fourteen groups. Besides the control animals, each mouse received a corresponding dose of heavy metal mixture [MPL (maximum permissible limit), 1 × , 5 × , 10 × , 50 × or 100 ×]. The mice were sacrificed, and blood was extracted. Si gnificant increase in the blood metal concentration was observed after exposure to multi-metal mixtures. The amount of As and Hg in the blood of mice subjected to high concentration of metal mixture was found more than tenfold high, whereas other metals (Cd, Pb, Ni, Cr) were less than threefold high with respect to each element in the blood of control animals. There was a noteworthy decline in the RBC count (32.1% male; 30.3% female) and HGB (30.68% male; 29.20% female) in the 100 × male and female groups. The enzymatic antioxidant system, such as SOD, CAT, GSH, and MDA, also mediates the relationship between heavy metal mixtures and hematological parameters. Serum ALT, AST, ALP, CR, and BUN significantly increased (p <  0.05) in multi-metal exposed group (50 × and 100 ×) indicating hepatic-renal cellular injuries. ...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research